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Mutation of dentin sialophosphoprotein and hereditary malformations of dentin

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Author:
No author available
Journal Title:
Chinese Journal of Stomatology
Issue:
1
DOI:
10.3760/cma.j.cn112144-20221009-00521
Key Word:
牙体发育异常;牙本质发育不全;牙本质发育不良;牙本质涎磷蛋白;基因突变;Odontodysplasia;Dentinogenesis imperfecta;Dentin dysplasia;Dentin sialophosphoprotein;Gene mutation

Abstract: The classification as well as the clinical manifestations of hereditary malformations of dentin are of great concern and have been deeply elucidated. The understanding of its genetic basis also increases progressively. Dentin sialophosphoprotein (DSPP) is the pathogenic gene of dentinogenesis imperfecta type Ⅱ, dentinogenesis imperfecta type Ⅲ and dentin dysplasia type Ⅱ. In this article, the classification of DSPP mutations as well as the resultant dysfunction of the mutant DSPP are summarized respectively and the corresponding clinical manifestations are analyzed. This work will provide a reference for the diagnosis and treatment of hereditary malformations of dentin.

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