Abstract： Burning mouth syndrome (BMS) is one of the most common mucosal diseases. Although a variety of therapies have been reported to treat BMS, there is a lack of widely recognized therapies and it is still a dilemma for clinicians to treat BMS. Led by the Chinese Stomatological Association, the first edition of evidence-based guideline for clinical practice of BMS was developed under the guidance of WHO Handbook for Guideline Development. The 27 recommendations were formed from the following 6 aspects: pre-treatment examination, removal of stimuli, medication, physical therapy, psychological therapy and antipsychotics. There are 3 strong recommendations and 12 weak recommendations in pre-treatment examination and removal of stimuli, as well as 12 weak recommendations in therapies, which could provide the references for clinical practice of BMS in China.