You Position: Home > Paper
Research advances in the v-raf murine sarcoma viral oncogene homolog gene mutation in ameloblastoma
( views:62, downloads:74 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Stomatology
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1002-0098.2018.07.016
- Key Word:
- 口腔肿瘤;成釉细胞瘤;BRAF基因;Mouth neoplasms;Ameloblastoma;BRAF gene
Abstract： V-raf murine sarcoma viral oncogene homolog B1 (BRAF) is a pro-oncogene, which is one member of the RAF family. Mutated BRAF is found in approximately 8% of human tumors. BRAF gene mutations lead to continuous activation of the mitogen-activatd protein kinase (MAPK) pathway, which resulting in abnormal cell proliferation and tumorigenesis. In recent years, recurrent MAPK signaling mutations were identified in ameloblastoma, among which BRAF-V600E is the most prominent type. This provides new strategies for the targeted treatment of ameloblastoma. This paper reviewed the latest advances in BRAF gene mutation associated with ameloblastoma and its potential clinical significance.
- [1]刘进忠,汪说之,陈新明,等.成釉细胞瘤肿瘤细胞巢周边及中心区细胞增殖和分化的研究[J].2002,(1).
- [2]Karoliina Jääskeläinen,Kowan J Jee,Ilmo Leivo,etc.Cell proliferation and chromosomal changes in human ameloblastoma[J].2002,136(1).
- [3]Helen, Davies,Graham R, Bignell,Charles, Cox,etc.Mutations of the BRAF gene in human cancer.[J].2002,417(6892).
- [4]Taye J, Lasisi,Akinyele O, Adisa,Adeola A, Olusanya.Appraisal of jaw swellings in a Nigerian tertiary healthcare facility.[J].2013,5(1).
- [5]Ajike, S. A.,Obuekwe, O. N.,Obimakinde, O. S.,etc.A prospective epidemiological study on odontogenic tumours in a black African population, with emphasis on the relative frequency of ameloblastoma[J].2015,44(9).
- [6]Sweeney,R.T.,McClary,A.C.,Myers,B.R.,etc.Identification of recurrent SMO and BRAF mutations in ameloblastomas[J].2014,46(7).
- [7]Y, TSUKADA,S, DELAPAVA,J W, PICKREN.Granular-Cell Ameloblastoma with Metastasis to the Lungs: Report of a Case and Review of the Literature.[J].1965,18.
- [8]Badalian Very G,Vergilio JA,Degar BA,etc.Recurrent BRAF mutations in Langerhans cell histiocytosis.[J].2010,116(11).
- [9]Faden, Daniel L.,Algazi, Alain.Durable treatment of ameloblastoma with single agent BRAFi Re: Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma[J].2017,109(1).
- [10]张旭东,陈瑞雪,王洁.BRAF基因突变与肿瘤[J].2017,(5).
- [11]袁溪,杜蓉,魏静,等.针对B-RAF突变的抗肿瘤靶向药物研究进展[J].2014,(8).
- [12]Paraiso KH,Fedorenko IV,Cantini LP,etc.Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy.[J].2010,102(12).
- [13]Sibel Elif Gültekin,Reem Aziz,Carina Heydt,etc.The landscape of genetic alterations in ameloblastomas relates to clinical features[J].2018,472(5).
- [14]McClary, Andrew C.,West, Robert B.,McClary, Ashley C.,etc.Ameloblastoma: a clinical review and trends in management[J].2016,273(7).
- [15]Pacini F,Marino C,Rossi ED,etc.BRAF(V599E) Mutation Is the Leading Genetic Event in Adult Sporadic Papillary Thyroid Carcinomas.[J].2004,89(5).
- [16]Harith, Rajagopalan,Alberto, Bardelli,Christoph, Lengauer,etc.Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.[J].2002,418(6901).
- [17]A Tannapfel,F Sommerer,M Benicke,etc.Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma[J].2003,52(5).
- [18]Hubing, Shi,Xiangju, Kong,Antoni, Ribas,etc.Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition.[J].2011,71(15).
- [19]Peter R Morgan,Ari Ristimaki,Klaus Elenius,etc.High frequency of BRAF V600E mutations in ameloblastoma[J].2014,232(5).
- [20]P, Brunner,M, Bihl,G, Jundt,etc.BRAF p.V600E mutations are not unique to ameloblastoma and are shared by other odontogenic tumors with ameloblastic morphology.[J].2015,51(10).
- [21]Brown,N.A.,Rolland,D.,McHugh,J.B.,etc.Activating FGFR2-RAS-BRAF mutations in ameloblastoma[J].2014,20(21).
- [22]Sheils OM,O'Leary JJ,Cantwell Dorris ER.BRAFV600E: implications for carcinogenesis and molecular therapy.[J].2011,10(3).
- [23]Varo P.,Alfthan G.,Aro A..Effects of Supplementation of Fertilizers on Human Selenium Status in Finland[J].1995,120(3).
- [24]Pinkel D,Fridlyand J,Brocker EB,etc.Distinct sets of genetic alterations in melanoma.[J].2005,353(20).
- [25]Liso A,Rabadan R,Ambrosetti A,etc.BRAF mutations in hairy-cell leukemia.[J].2011,364(24).
- [26]Kaye, Frederic J.,Ivey, Alison M.,Drane, Walter E.,etc.Clinical and Radiographic Response With Combined BRAF-Targeted Therapy in Stage 4 Ameloblastoma[J].2015,107(1).
- [27]Diniz, Marina Goncalves,Gomes, Carolina Cavalieri,Antonini Guimaraes, Bruna Viana,etc.Assessment of BRAFV600E and SMOF412E mutations in epithelial odontogenic tumours[J].2015,36(7).