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Research advances in the v-raf murine sarcoma viral oncogene homolog gene mutation in ameloblastoma

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Journal Title:
Chinese Journal of Stomatology
Key Word:
口腔肿瘤;成釉细胞瘤;BRAF基因;Mouth neoplasms;Ameloblastoma;BRAF gene

Abstract´╝Ü V-raf murine sarcoma viral oncogene homolog B1 (BRAF) is a pro-oncogene, which is one member of the RAF family. Mutated BRAF is found in approximately 8% of human tumors. BRAF gene mutations lead to continuous activation of the mitogen-activatd protein kinase (MAPK) pathway, which resulting in abnormal cell proliferation and tumorigenesis. In recent years, recurrent MAPK signaling mutations were identified in ameloblastoma, among which BRAF-V600E is the most prominent type. This provides new strategies for the targeted treatment of ameloblastoma. This paper reviewed the latest advances in BRAF gene mutation associated with ameloblastoma and its potential clinical significance.

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