Abstract: Objective To explore the clinical application of home-made temporomandibular joint (TMJ) prostheses.Methods Self-developed TMJ prostheses were applied for end stage osteoarthritis,TMJ ankylosis,condylar tumors after biomechanical examination.The stability of the prostheses toward bone was evaluated during operation.Post-operative CT scans and clinical follow-ups were taken to check changes of mouth opening,position of the prostheses,bone resorption around the screws,and heterotopic bone formation around artificial condyle.Results There were 6 patients accepted 7 prostheses smoothly without infection and other complications.Post-operative follow-ups were from 6 to 13 months with a mean of 7.6 months.Mouth opening was significantly improved from (16.2± 14.4) mm before operation to (31.5±4.8) mm during follow-ups (P=0.01).All prostheses were stable without screw loose and heterotopic bone formation.Conclusions Home-made TMJ prostheses were stable after primary clinical application,but the long-term results need to be observed.