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Histopathological analysis of oral lichen planus with malignant transformation

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Author:
No author available
Journal Title:
Chinese Journal of Stomatology
Issue:
12
DOI:
10.3760/cma.j.issn.1002-0098.2016.12.004
Key Word:
扁平苔藓,口腔;病理学,口腔;病理诊断;癌变;Lichen planus,oral;Pathology,oral;Malignant transformation;Pathology

Abstract: Objective To estimate the histological features of oral lichen planus (OLP) which underwent malignant transformation and discuss the current problems in OLP pathological diagnosis.Methods Using the modified WHO OLP criteria (2003),reevaluated the pathological changes of cases diagnosed initially as OLP and transformed into squamous cell carcinomas indicated by subsequent biopsies.Results Among 3 721 cases of OLP clinically and pathologically diagnosed during 1984 and 2015,there were 19 cases (0.51%) having underwent malignant transformation.Reevaluation of the initial biopsies revealed that 10 cases did not meet the criteria of 0LP,as without characteristic basal cell liquefaction,not exhibiting sufficient band-like lymphocytes infiltration,or presenting with epithelial dysplasia.There were 9 cases of OLP malignant transformation left after the reevaluation.Conclusions Pathological diagnosis of 0LP should fully fit the criteria i.e.basal cell liquefaction,typical band-like lymphocytes infiltration and absence of epithelial dysplasia,which is also a prerequisite for researches in malignant transformation of OLP.

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