Abstract： Objective To access the effect of wireless biofeedback therapy on bruxism.Methods Ten voluntary bruxers (seven female and three male,mean age 26.1 years) were invited to participate in this clinical research.An electric resistance strain gauge was embedded in the position of canine of a maxillary splint for monitoring the abnormal clenching or grinding movement of teeth during sleep.The relevant details of bruxism events,including value of relative force,occurring time and duration were recorded and analyzed by the receiver device and monitoring program respectively.Meanwhile,for the purpose of nerve system and muscle relaxation,a watch-style device around the patient's wrist will vibrate to alert the patient of teeth grinding or clenching if the value of biting force and duration exceed the threshold.Total average episodes of bruxism and duration was observed during eight hours sleep,and was analyzed with one-way analysis of variance in SPSS 19.0 by the end of 6th week and three months following biofeedback therapy.Results The average episodes of bruxism has declined dramatically from (9.8 ± 2.2) times to (3.0 ± 1.2) times during one night (P ＜ 0.05),and the average duration of bruxism events was reduced from (20.7 ± 12.2) s to (10.0 ± 3.4) s (P ＜ 0.05) after six weeks biofeedback therapy.By the end of three months,the average episodes declined to (2.9 ± 1.2) times(P ＜0.05),and the average duration decline to (9.2 ± 2.9) s (P ＜ 0.05) with contrast to preliminary night.Conclusions The pressure-based wireless biofeedback device is able to monitoring clenching and grinding of bruxism.The results suggest that biofeedback therapy may be an effective,novd and convenient measure for treatment of bruxism according to several months therapy.