Abstract： Objective To investigate the clinical characteristics,pathological and biological behaviors of oral squamous cell carcinomas(OSCC) originated from oral submucous fibrosis(OSF). Methods A total of 528 patients with OSCC treated at Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University from 2002 to 2010 were divided into two groups, OSCC originated from OSF and OSCC not originated from OSF. The clinical data regarding age, gender, location, pathological type, metastasis and recurrence rate of these patients were analyzed retrospectively. ResultsThe mean age of the group of OSCC originated from OSF (45.8 years) was younger than that of the group of OSCC not originated from OSF(55.9 years). The and recurrence rate of the group of OSCC originated from OSF(13.5%, 39.1%)was higher than that of the group of OSCC not originated from OSF(7.6%, 27.8%.). Conclusions OSCC originated from OSF occurs at younger age and more in male, and is clinically more invasive and metastatic.