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Recent advances in research of relationship between hypoxia and epithelial mesenchymal transition in head and neck cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1002-0098.2011.04.016
- Key Word:
- No keyword available
Abstract： @@ 乏氧广泛存在于包括头颈肿瘤在内的多种恶性实体瘤中,可引起肿瘤细胞适应性变化,导致肿瘤抗拒辐射、耐受化疗及侵袭转移.其中乏氧诱导因子(hypoxia inducible factor,HIF)发挥着核心调控作用.上皮间质转型(epithelial mesenchymal transition,EMT)是上皮细胞向间质细胞转化的现象,在胚胎发育、伤口愈合、纤维化病变及肿瘤的发生发展和侵袭转移中发挥着重要作用.
- [1]Jun, Wan,Jinben, Ma,Ju, Mei,etc.The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells.[J].2009,28.
- [2]Sahlgren, C,Gustafsson, MV,Jin, S,etc.Notch signaling mediates hypoxia-induced tumor cell migration and invasion[J].2008,105(17).
- [3]Riesco Eizaguirre G,Rodriguez I,De la Vieja A.The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer.[J].2009,69(21).
- [4]Guofei, Zhou,Laura A, Dada,Minghua, Wu,etc.Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.[J].2009,297(6).
- [5]Raman V,Sasser AK,Hall BM,etc.Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.[J].2009,28(33).
- [6]Arany Z,Foo SY,Ma Y,etc.HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.[J].2008,451(7181).
- [7]Sulkowska M,Wincewicz A,Sulkowski S,etc.Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients.[J].2009,41(3).
- [8]Semenza GL.Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.[J].2010,29(5).
- [9]Hector Peinado.A hypoxic twist in metastasis[J].2008,10(3).
- [10]Haase VH.Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease.[J].2009,76(5).
- [11]Tomas, Regueira,Philipp M, Lepper,Sebastian, Brandt,etc.Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes.[J].2009,29(10).
- [12]Roche O,Jewett MA,Gervais ML,etc.VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail.[J].2007,27(1).
- [13]Davidson B,Reich R,Stavnes HT,etc.Mesenchymal-to-epithelial transition determinants as characteristics of ovarian carcinoma effusions.[J].2010,27(3).
- [14]Kohei, Miyazono.Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer.[J].2009,85(8).
- [15]Chen J,Imanaka N,Chen.Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion.[J].2010,102(2).
- [16]Portillo F,Cano A,Peinado H.Switching on-off Snail: LOXL2 versus GSK3beta.[J].2005,4(12).
- [17]Copple,B.L..Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms[J].2010,30(5).
- [18]Kantola S,Dayan D,Yahalom R,etc.Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma.[J].2010,127(6).
- [19]Marjon A, Smit,Thomas R, Geiger,Ji-Ying, Song,etc.A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis.[J].2009,29(13).