You Position: Home > Paper
Effects of clotrimazole on the growth of oral squamous cell carcinoma
( views:198, downloads:12 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1002-0098.2010.09.009
- Key Word:
- 癌,鳞状细胞;克霉唑;细胞周期;Carcinoma,squamous cell;Clotrimazole;Cell cycle
Abstract： Objective To investigate the effects of clotrimazole on the growth of oral squamous cell carcinoma (OSCC). Methods OSCC-25 cells growing in log phase were treated with various doses of clotrimazole. The concentration of IC50, cell cycle and cell cycle related protein were examined. Results The concentration of clotrimazole for inhibiting OSCC was IC50, 8. 51 μmol/L. Clotrimazole induced cell cycle arrest in the G0-G1, cell cycle phase, with a concomitant decrease of cells in the G2-M and S-phase. Furthermore, clotrimazole significantly decreased the levels of cyclin D, cyclin E and CDK-4. Conclusions Clotrimazole inhibits the growth of OSCC.
- [1]L R, Benzaquen,C, Brugnara,H R, Byers,etc.Clotrimazole inhibits cell proliferation in vitro and in vivo.[J].1995,1(6).
- [2]Raed A.Al-Qawasmeh,Leo Lau,Ming Wang,etc.NC381, a Novel Anticancer Agent, Arrests the Cell Cycle in G_0-G_1 and Inhibits Lung Tumor Cell Growth in Vitro and in Vivo[J].2004,308(2).
- [3]Ito C,Coustan Smith E,Pui CH,etc.The antifungal antibiotic clotrimazole alters calcium homeostasis of leukemic lymphoblasts and induces apoptosis.[J].2002,16(7).
- [4]H, Weuta.Clinical studies with oral clotrimazole.[J].1974,50 Suppl 1.
- [5]M E, Forgue-Lafitte,A M, Coudray,D, Fagot,etc.Effects of ketoconazole on the proliferation and cell cycle of human cancer cell lines.[J].1992,52(24).
- [6]Aktas H,Fluckiger R,Acosta JA,etc.Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole.[J].1998,95(14).
- [7]Scully C,Bagan JV.Recent advances in Oral Oncology 2007: imaging, treatment and treatment outcomes.[J].2008,44(3).
- [8]Coghlan MJ,Parihar AS,Gopalakrishnan M,etc.Effects of intermediate-conductance Ca(2+)-activated K(+) channel modulators on human prostate cancer cell proliferation.[J].2003,471(3).
- [9]Beitner R,Penso J.Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells.[J].1998,342(1).
- [10]Khalid MH,Shibata S,Hiura T.Effects of clotrimazole on the growth, morphological characteristics, and cisplatin sensitivity of human glioblastoma cells in vitro.[J].1999,90(5).
- [11]M, Seo,H, iida,Y, Miura.Basic experiments with clotrimazole administered orally.[J].1977,5(2).
- [12]Heike, J?ger,Tobias, Dreker,Anita, Buck,etc.Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro.[J].2004,65(3).
- [13]C J, Sherr,J M, Roberts.CDK inhibitors: positive and negative regulators of G1-phase progression.[J].1999,13.
- [14]H, Mukhtar,B J, Del Tito,M, Das,etc.Clotrimazole, an inhibitor of epidermal benzo(a)pyrene metabolism and DNA binding and carcinogenicity of the hydrocarbon.[J].1984,44(10).
- [15]Yao HL,Wang ZH,Jia YC,etc.Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer.[J].2007,26(35).
- [16]Caputy AJ,Khalid MH,Walters E,etc.Inhibition of tumor growth and prolonged survival of rats with intracranial gliomas following administration of clotrimazole.[J].2005,103(1).
- [17]Penso J,Beitner R.Clotrimazole decreases glycolysis and the viability of lung carcinoma and colon adenocarcinoma cells.[J].2002,451(3).
- [18]Pestell RG,Albanese C,Lee RJ,etc.The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation.[J].1999,20(4).
- [19]Jon, Sudb.Novel management of oral cancer: a paradigm of predictive oncology.[J].2004,2(4).