Abstract： Objective To evaluate the effects and mechanisms of the mieroscrew implant anchorage (MIA) combined with multi-loop edgewise arch wire (MEAW) technique in the treatment of skeletal Class Ⅱ. Adult patients. Methods Eleven adult patients with skeletal Class Ⅱ high-angle maloeelusions were treated with fixed appliances. The spaces were closed by the springs from the MIA to the hook on the arehwire. The height of the hook and the direction of the force were different according to the intrusion and retraction of upper anterior teeth. In the finishing stage, MEAW technique and modified class Ⅱ elastics (from the first loop of MEAW to the MIA) were used for final detailing. Cephalometric analysis was used to evaluate the effect after treatment. Results After treatment, the decrease of SNA, ANB and FMA were ( 2. 86 ± 1.05 )° , ( 2. 82±0. 96 )° and ( 2.95 ± 1.35 )° , respectively. The torque control of upper anterior teeth was good. The protrusion of lower incisors and the molar extrusion were avoided. The upper molars were moved distally by ( 3. 00 ± 2. 19) nun. Conclusions The treatment of adult patients with skeletal Class Ⅱ high angle maloeelusions with MIA and MEAW technique could not only improve the facial esthetics but also avoided the common side effects of traditional Class Ⅱ elastics .