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Proteomics study of the serum biomarkers in tongue cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1002-0098.2007.09.012
- Key Word:
- 舌肿瘤;癌,鳞状细胞;生物学标记
Abstract： 目的 通过运用蛋白质组学技术寻找舌癌血清特异性标记物,为舌癌早期诊断、病程监测以及预后判断提供可靠的血清学指标.方法 采用舌癌Tca8113细胞系体外培养,并移植于裸鼠.以正常裸鼠血清为对照,采用双向凝胶电泳分离技术分析荷瘤小鼠的血清蛋白表达谱,并通过质谱鉴定差异表达蛋白.结果 在荷瘤裸鼠血清中分离和鉴定了5个差异表达蛋白,其中鳞状细胞癌抗原1检索得分最高,为97分,定量分析中变化最大,并与舌癌密切相关.结论 荷瘤裸鼠血清中鳞状细胞癌抗原1高表达,有望成为舌癌的特异性血清标记物之一.
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