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Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1002-0098.2007.04.012
- Key Word:
- 癌,疣状;癌,鳞状细胞;基因表达
Abstract： 目的 研究口腔疣状癌与口腔鳞癌组织基因的差异表达,探讨口腔疣状癌(oral verrucous carcinoma,OVC)与口腔鳞癌(oral squamous cell carcinoma,OSCC)的基因学基础.方法 应用cDNA芯片技术对4例OVC和4例OSCC组织mRNA检测,通过芯片杂交、生物信息学处理,找出两者间差异表达基因.结果 BioStarH-40芯片发现差异表达基因593条,差异表达基因占15.2%,其中表达增强283条(显著增强59条),表达降低310条(显著降低98条).结论 OVC与OSCC基因表达比较,差异有统计学意义,这些差异可能在各自不同的生物学行为中起重要作用.
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