You Position: Home > Paper
Association of vitamin D receptor gene polymorphisms with the susceptibility to chronic periodontitis of Han nationality
( views:227, downloads:64 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1002-0098.2005.01.017
- Key Word:
- 牙周炎;受体,骨化三醇;疾病易感性;基因多态性
Abstract： 目的探讨维生素D受体(VDR)基因多态性与汉族人群慢性牙周炎(CP)易感性的关系.方法收集汉族轻、中、重度CP患者共166例及80名无牙周炎对照者的颊黏膜拭子,以Chelex-100法提取DNA,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法测定VDR BsmI、VDR ApaI和VDR TaqI的基因型,分析组间基因型分布和等位基因频率的差异.结果轻、中、重度CP患者中VDR ApaI等位基因A携带者明显多于对照组,重度CP与中度CP、重度CP与轻度CP患者间VDR ApaI基因型的分布差异均有统计学意义,中度CP与轻度CP患者间VDR Apal基因型分布差异无统计学意义,而VDR BsmI、TaqI位点的基因型分布在患者组和对照组间差异无统计学意义.结论 VDR ApaI 等位基因A可能与汉族人群CP的易感性有关.
- [1]王晓敏,杨宗萍,于世凤.阿仑膦酸钠防治牙槽骨吸收的实验研究[J].2001,(3).
- [2]段海燕,章锦才,黄萍,等.四种方法获取DNA用于检测IL-1基因多态性的比较分析[J].2001,(1).
- [3]钟良军,张蕴惠,章锦才,等.白细胞介素1基因多态性与维吾尔族群体慢性牙周炎易感性的关系[J].2002,(5).
- [4]钱伟,章锦才,张蕴惠.肿瘤坏死因子A-308位点基因多态性与成人重度牙周炎的关系[J].2002,(2).
- [5]Ingles SA,Coetzee GA,Durrin LK,etc.Vitamin D receptor 3'-untranslated region polymorphisms: lack of effect on mRNA stability.[J].1999,1453(3).
- [6]N A, Morrison,R, Yeoman,P J, Kelly,etc.Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin.[J].1992,89.
- [7]D, Feldman.Androgen and vitamin D receptor gene polymorphisms: the long and short of prostate cancer risk.[J].1997,89.
- [8]Wang HY,Duff GW,Wu Y,etc.Low prevalence of a periodontitis-associated interleukin-1 composite genotype in individuals of Chinese heritage.[J].2000,71(2).
- [9]Hennig BJ,Chapple IL,Heasman PA,etc.Association of a vitamin D receptor gene polymorphism with localized early-onset periodontal diseases.[J].1999,70(9).
- [10]A, Gough,P, Sambrook,J, Devlin,etc.Effect of vitamin D receptor gene alleles on bone loss in early rheumatoid arthritis.[J].1998,25.
- [11]H. Löe,A. Anerud,H. Boysen,etc.Natural history of periodontal disease in man[J].1986,13(5).
- [12]S, Farrow.Allelic variation and the vitamin D receptor.[J].1994,343(8908).
- [13]Cao CF,Tachi Y,Meng HX,etc.Relationship between vitamin D receptor gene polymorphism and periodontitis.[J].2002,37(4).
- [14]Valenzuela A,Garcia A,Garcia-Lozano JR,etc.Association of vitamin D receptor genotypes with early onset rheumatoid arthritis.[J].2001,28(1).
- [15]B S, Michalowicz,D, Aeppli,J G, Virag,etc.Periodontal findings in adult twins.[J].1991,62.