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Epstein-Barr virus infection in benign lymphoepithelial lesions with malignant transformation of salivary glands
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1002-0098.2004.04.008
- Key Word:
- 疱疹病毒4型,人;涎腺肿瘤;原位杂交;聚合酶链反应
Abstract： 目的了解Epstein-Barr病毒(EBV)感染与涎腺良性淋巴上皮病损恶变的关系.方法采用针对EB病毒编码的小分子RNA(EBER-1)的寡核苷酸探针对2例涎腺良性淋巴上皮病损灶性恶变、14例恶性淋巴上皮病损(MLEL)、4例良性淋巴上皮病损(BLEL)、4例非特异性慢性涎腺炎石蜡包埋组织进行原位杂交检测;采用聚合酶链反应(PCR)进行EBV BamHI-W片段检测.结果2例良性淋巴上皮病损灶性恶变形态学上良性区域或恶性区域,EBER-1及EBV BamHI-W片段均为阳性,14例MLEL的癌细胞核均可见EBER-1强阳性信号,其中12例EBV BamHI-W片段阳性,4例BLEL及4例非特异性慢性涎腺炎均为阴性.结论少数恶性淋巴上皮病损可能在BLEL基础上发生,EB病毒感染与涎腺良性淋巴上皮病损癌变发生可能有密切关系,EBV感染可发生在BLEL癌变形态学改变之前.
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