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RD抗涎腺腺样囊性癌细胞转移的体外实验研究
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1002-0098.2001.06.021
- Key Word:
- 涎腺;癌,腺样囊性;肿瘤转移
Abstract： 目的研究精氨酸-天冬氨酸(RD)抗涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)转移的作用.方法 MTT法测定RD对SACC-LM与纤维粘连蛋白、层粘连蛋白、Ⅳ型胶原粘连的影响,用改良Boyden chamber方法观察RD对SACC细胞人工重组基底膜侵袭以及趋化运动能力的作用.结果 RD在5 mg/L时能抑制SACC-LM与细胞及纤维粘连蛋白的粘附,而对SACC-LM与层粘连蛋白、Ⅳ型胶原的粘附无明显作用.RD在1、5、25 mg/L时能明显抑制SACC-LM对人工基底膜的侵袭.RD在25 mg/L时能抑制SACC-LM的趋化运动.结论体外实验表明RD有抗SACC转移的作用.
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