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The mechanism and research progress of the effects on different types muscle tissue by the advanced glycation end products

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Author:: No author available

Journal Title:: Chinese Journal of Health Management

Issue:: 9

DOI:: 10.3760/cma.j.cn115624-20211209-00752

Key Word:: 糖尿病;晚期糖基化终末产物;骨骼肌;平滑肌;心肌

Abstract：晚期糖基化终末产物（advanced glycation end products，AGEs）在组织中的不断积累是糖尿病并发症发生和进展的重要原因之一。其中，糖尿病所引发的肌肉组织相关并发症也被认为与AGEs高度相关。机体中主要存在骨骼肌、心肌和平滑肌等三种不同的肌肉组织，当AGEs在这三种肌肉组织中累积时，将严重影响其结构和相关功能。然而，AGEs所导致的不同肌肉组织发生功能障碍的机制并不完全相同，因此，本文对AGEs对骨骼肌、心肌和平滑肌等不同肌肉组织的影响方式及作用机制进行综述，以期为临床糖尿病肌肉组织相关并发症的诊断、治疗和后续相关研究提供参考。

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