Paper - WANFANG MED ONLINE

You Position: Home > Paper

Serum immunoglobulin M concentration and triglyceride levels in adults without diabetes and hypertension

( views:61, downloads:93 )

Author:: No author available

Journal Title:: Chinese Journal of Health Management

Issue:: 2

DOI:: 10.3760/cma.j.issn.1674-0815.2016.02.017

Key Word:: No keyword available

Abstract：肥胖在全球范围呈激增态势,是慢性疾病的主要危险因素之一.慢性低水平炎症被认为是由肥胖引起的慢性疾病的一个重要的中间病理过程[1-3].胰岛β细胞受损和胰岛素抵抗会引起脂代谢和糖代谢紊乱,代谢紊乱又是2型糖尿病、心血管疾病发病的重要因素[4-5].最近有研究表明IgM的增高与由肥胖引起的抗原暴露有关[6].IgM由B1细胞分泌,是机体体液免疫过程中最先分泌的抗体[7].三酰甘油(TG)作为脂肪酸的载体能够通过脂蛋白脂肪酶释放脂肪酸进入组织和血液中,使脂肪酸增高.一项动物实验表明,在内脏脂肪组织中的饱和脂肪酸通过刺激B细胞的toll样受体4使IgM水平增高[8].同时TG水平升高会促进氧化应激反应[9],从而导致IgM水平增高.我们设计了一项横断面研究探讨TG水平与IgM浓度的关联.

Reference

[1]Paolo Marzullo,Alessro Minocci,Paola Giarda,etc.Lymphocytes and immunoglobulin patterns across the threshold of severe obesity[J].2014,45(3).
[2]María Isabel, Burgos Alves,Francisco, Avilés Plaza,Rebeca, Martínez-Tomás,etc.Oxidized LDL and its correlation with lipid profile and oxidative stress biomarkers in young healthy Spanish subjects.[J].2010,66(3).
[3]Sato K,Kaburagi T,Nakano M,etc.The influence of a high-fat dietary environment in the fetal period on postnatal metabolic and immune function.[J].2010,18(9).
[4]Faas MM,Bouman A,Heineman MJ.Sex hormones and the immune response in humans.[J].2005,11(4).
[5]Campos J,Gonzalez-Quintela A,Meijide LM,etc.Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities.[J].2008,151(1).
[6]Chen,B.-W.,Dang,A.-M..Sleep duration and hypertension: Flawed methods call the conclusions into question[J].2013,14(12).
[7]Arlan L, Rosenbloom.Obesity, Insulin Resistance, beta-Cell Autoimmunity, and the Changing Clinical Epidemiology of Childhood Diabetes.[J].2003,26(10).
[8]Kawai,Y.,Miyashita,H.,Otaki,N.,etc.Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: Involvement of electronegative potential of antigens[J].2013,288(19).
[9]Homeira, Rashidi,Seyed Peyman, Payami,Seyed Mahmoud, Latifi,etc.Prevalence of metabolic syndrome and its correlated factors among children and adolescents of Ahvaz aged 10 - 19.[J].2014,13.
[10]Kimura, S.,Yoshimura, M.,Horikawa, C.,etc.Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults.[J].2009,54(3).
[11]Jan Galle,Thomas Hansen-Hagge,Christoph Wanner,etc.Impact of oxidized low density lipoprotein on vascular cells[J].2006,185(2).
[12]Zhang, Lu,Zhang, Zhenzhen,Zhang, Yurong,etc.Evaluation of Finnish Diabetes Risk Score in Screening Undiagnosed Diabetes and Prediabetes among U.S. Adults by Gender and Race: NHANES 1999-2010.[J].2014,9(5).
[13]Quan,W.,Jo,etc.Role of pancreatic β-cell death and inflammation in diabetes[J].2013,15(S3).
[14]Daniel A. Winer,Shawn Winer,Melissa H. Y. Chng,etc.B Lymphocytes in obesity?related adipose tissue inflammation and insulin resistance[J].2014,71(6).
[15]Fabiana de Miranda Moura dos Santos,Mariane Curado Borges,Rosa Weiss Telles,etc.Excess weight and associated risk factors in patients with systemic lupus erythematosus.[J].2013,33(3).
[16]Solinas G,Karin M.JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction.[J].2010,24(8).
[17]Doria A,Shoenfeld Y,Sherer Y,etc.Inflammation and accelerated atherosclerosis: basic mechanisms.[J].2005,31(2).
[18]Marco M, Ciccone,Giovanni, De Pergola,Maria T, Porcelli,etc.Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage?[J].2010,10.
[19]Buscemi,S.,Sprini,D.,Grosso,G.,etc.Impact of lifestyle on metabolic syndrome in apparently healthy people[J].2014,19(2).
[20]Jing, Sun,Nicholas J, Buys,Andrew P, Hills.Dietary pattern and its association with the prevalence of obesity, hypertension and other cardiovascular risk factors among Chinese older adults.[J].2014,11(4).
[21]Hamamci EO,Bostanoglu S,Cosgun E,etc.Comparison of early and late changes in immunoglobulins and acute phase reactants after laparoscopic adjustable gastric banding in patients with morbid obesity.[J].2010,20(5).
[22]Shi H,Kokoeva MV,Inouye K,etc.TLR4 links innate immunity and fatty acid-induced insulin resistance.[J].2006,116(11).
[23]Boes M.Role of natural and immune IgM antibodies in immune responses.[J].2000,37(18).
[24]Binder CJ.Natural IgM antibodies against oxidation-specific epitopes.[J].2010,30(Suppl.1).
[25]Angeliki Nikolopoulou,Nikolaos PE Kadoglou.Obesity and metabolic syndrome as related to cardiovascular disease[J].2012,10(7).