Abstract： Objective To investigate the quality of life (QOL) of hemodialysis patients and its influencing factors.Methods One hundred and twenty-five patients who underwent maintenance hemodialysis treatment for more than 3 months were selected,and their age,gender,combined disease and dialysis status were recorded.Hemoglobin,albumin and urea clearance index (Kt/V) were tested.Charlson complications index,Karnofsky activity index,Hamilton Depression Scale and MOS 36-item short health survey questionnaire were used to assess complication,activity,and psychological situation of the patients.Results Of the 125 patients,there were 7 (5.6％) grade 1 patients (could not take care of themselves),43 (34.4％) grade 2 patients (could only take care of themselves),47 (37.6％) grade 3 patients,and 13 (10.4％) grade 4 patients.A significant relationship between rehabilitation status and age was found.Young patients were better than older patients (x2 =5.864,P ＜ 0.05).The majority of grade 1 patients were older and had been diagnosed with diabetes,and their Karnofsky activity index,Charlson complications index and Hamilton Depression Scale index were lower than Grade 2-4 patients(t values were 5.263,7.866,6.215 and 5.474,respectively; all P ＜ 0.05).The QOL of the patients were related with age,diabetes,dialysis,serum albumin level,activity index,index of Charlson complications and Hamilton depression (r =-0.618,-0.512,0.593,0.369,0.801,-0.696 and-0.516,respectively).Conclusions The QOL of maintenance hemodialysis patients may be related with physical,psychological,and many other factors.It should be needed to strengthen health care and emotional support to the patients.