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光学相干断层扫描成像在气道疾病中的应用研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 10

DOI:: 10.3760/cma.j.issn.1001-0939.2018.10.013

Key Word:: No keyword available

Abstract：慢性阻塞性肺疾病(慢阻肺)、支气管哮喘(哮喘)和支气管肺癌是严重影响人类健康的常见气道疾病.目前对气道疾病的诊断技术主要有CT、体外高频超声及呼吸介入技术等,但CT分辨率不高,对肺外周气道诊断价值有限,且具有一定的辐射剂量[1-2];体外高频超声限于组织分辨率低[3],而且仅可探及颈部气管段,无法对位于胸腔内的气道清晰成像;支气管镜检查只可在肉眼直视下观察气道腔内情况,经支气管镜活检仅能反映局部组织形态,而支气管径向超声的显像对气道壁分层的分辨率欠佳[4-6].对以小气道病变为主的慢性气道疾病,目前临床常用的诊断技术均难以直接观察小气道的形态改变,评估小气道结构重塑仍然是一大难题和挑战.

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