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屋尘螨提取液对人支气管哮喘气道上皮细胞-间质转化的影响
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Tuberculosis and Respiratory Diseases
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1001-0939.2017.03.019
- Key Word:
- No keyword available
Abstract： 气道重塑在支气管哮喘(哮喘)的疾病转归中发挥重要作用,因此越来越受到重视. 哮喘患者的气道组织中存在上皮细胞-间质转化(epithelial-mesenchymal transition,EMT)的现象,即上皮细胞失去上皮细胞特征(如E-钙黏蛋白),获得间质细胞特征如波形蛋白及α-平滑肌肌动蛋白(α-SMA )等[1]. 气道上皮细胞EMT改变是气道重塑早期改变,因此探索哮喘气道上皮细胞EMT的相关机制有利于早期防治气道重塑. 动物实验结果显示,屋尘螨提取物( house dust mite extracets,HDM)可引起气道上皮发生EMT而参与哮喘气道重塑[2] ,但因体内环境受体神经、体液调节等多种因素的影响,无法明确HDM与上皮细胞EMT的直接关系. 本文通过HDM刺激体外培养的人支气管上皮细胞16-HBE观察过敏原对哮喘EMT过程的影响及可能机制.
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