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持续气道正压通气治疗对睡眠呼吸暂停患者心血管事件的研究结果的解读

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 3

DOI:: 10.3760/cma.j.issn.1001-0939.2017.03.004

Key Word:: No keyword available

Abstract： 2016年第10期N Engl J Med刊登了持续气道正压通气( CPAP)治疗对睡眠呼吸暂停患者心血管事件的研究( SAVE )结果及其对应的专家述评[ 1-2 ] ,引起了医学界极大的关注. SAVE研究是一项国际多中心、开放、平行、前瞻性的随机对照试验,目的是观察中重度阻塞性睡眠呼吸暂停( OSA)合并心脑血管疾病患者,在常规治疗基础上运用CPAP治疗,能否降低心脑血管的再发率及病死率,是一项具有里程碑意义的睡眠医学临床研究. 入组患者来自亚洲、美洲和欧洲的7个国家、89个临床中心,共纳入患者2717例,其中63%的患者来自中国,经过8年的临床观察,结果显示CPAP治疗并不能有效预防OSA患者心脑血管事件的再发生.

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