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长链非编码RNA在呼吸系统疾病中的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 11

DOI:: 10.3760/cma.j.issn.1001-0939.2016.11.015

Key Word:: No keyword available

Abstract：人类基因组大约只有2×104个蛋白编码基因,所占比例不到全基因组的2％,其余的基因都不编码蛋白质,这部分核酸序列曾被认为是“垃圾序列”.近年大规模的基因测序使人们对基因组结构有了更深入的了解,揭示了细胞内多个分子多环节作用导致了疾病的发生发展,一些非编码基因也在其中发挥了重要的作用.近年研究结果发现长链非编码RNA(long noncoding RNA,lncRNA)在多种呼吸系统疾病的发生、发展过程中发挥作用,本文简要介绍lncRNA基本概念、作用机制及研究方法,对相关研究进展综述如下.

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