You Position: Home > Paper
关注药物性睡眠低通气
( views:154, downloads:297 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Tuberculosis and Respiratory Diseases
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1001-0939.2016.08.004
- Key Word:
- No keyword available
Abstract： 随着急慢性疼痛的规范化治疗策略的推广及人们对生活质量要求的提升,阿片类与镇静催眠类药物的应用日趋广泛[1],相关副作用也受到重视,特别是其对睡眠期呼吸的影响.长期应用上述药物与睡眠呼吸障碍(SDB)的发生率及相关病死率有关[2-3],且睡眠猝死风险增加与应用频度和持续时间相关.阿片类与镇静催眠类药物除可导致阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)、药物性中枢性睡眠呼吸暂停(central sleep apnea,CSA)[4]以外,还可引起睡眠期低通气[副.药物性睡眠低通气(sleep related hypoventilation due to a medication orsubstance)定义为药物或物质引起的睡眠期肺泡通气不足,导致高碳酸血症,但应除外神经肌肉疾病、肺实质病变等基础疾病.
- [1]李庆云,王琼.聚焦新版睡眠相关呼吸疾病的国际分类[J].2014,(12).
- [2]李庆云,王琼.中枢性睡眠呼吸暂停综合征[J].2015,(9).
- [3]韩芳.肺泡低通气及低通气综合征[J].2015,(9).
- [4]James M, Walker,Robert J, Farney,Steven M, Rhondeau,etc.Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing.[J].2007,3(5).
- [5]Arora, N.,Cao, M.,Javaheri, S..Opioids, Sedatives, and Sleep Hypoventilation[J].2014,9(3).
- [6]Greer JJ,Ren J.Ampakine therapy to counter fentanyl-induced respiratory depression.[J].2009,168(1).
- [7]Dahl JL,Ryan KM,Joranson DE,etc.Trends in medical use and abuse of opioid analgesics.[J].2000,283(13).
- [8]Selim,B.J.,Junna,M.R.,Morgenthaler,T.I..Therapy for sleep hypoventilation and central apnea syndromes[J].2012,14(5).
- [9]Teichtahl, Harry,Wang, David,Cunnington, David,etc.Ventilatory Responses to Hypoxia and Hypercapnia in Stable Methadone Maintenance Treatment Patients.[J].2005,128(3).
- [10]Zutler M,Holty JE.Opioids, sleep, and sleep-disordered breathing.[J].2011,17(15).
- [11]Smith TW,Aarts L,Dahan A.Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression.[J].2010,112(1).
- [12]Mohler H,Mandelli M,Rudolph U,etc.Molecular targets for the myorelaxant action of diazepam.[J].2001,59(3).