The clinical significance of the levels of serum KL-6 mucin and interleukin-13 in pulmonary alveolar proteinosis
- Author:
- No author available
- Journal Title:
- Chinese Journal of Tuberculosis and Respiratory Diseases
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1001–0939.2015.02.011
- Key Word:
- 肺泡蛋白沉积症;KL-6黏蛋白;白细胞介素13;Pulmonary alveolar proteinos is;KL-6 mucin;Interleukin-13
Abstract： Objective To explore the serum levels of KL-6 mucin and interleukin 13 (IL-13) in patients with pulmonary alveolar proteinosis (PAP) and to investigate their clinical significance.Methods The serum levels of KL-6 and IL-13 were measured in 54 patients with PAP and in 50 healthy volunteers.The relationships among clinical features,chest high resolution computed tomography image scores,serum KL-6 levels and serum IL-13 levels were analyzed.Results The serum levels of IL-13 in PAP patients were significantly higher than those in healthy controls [(23 ± 14) ng/L vs.(13 ± 9) ng/L,t =3.71,P ＜ 0.05].The serum levels of IL-13 did not associate with lung function and image scores.The serum levels of KL-6 [median (inter quartile range) U/ml] were higher in PAP patients than those in healthy controls [3498.50 (1 160.50-9 337.75) U/mlvs.177.00 (147.50-255.00) U/ml,U=6.00,P＜0.05].The value of KL-6 negatively correlated with FVC ％ predicted,FEV1％ predicted,DLCO％ predicted,and PaO2 (r =-0.591,-0.563,-0.529,and-0.618,P ＜ 0.05) ; however positively correlated with serum lactate dehydrogenase,the degree of lung opacification opacity,ground glass opacity extent,ground glass opacity severity and reticulation extent (r =0.645,0.733,0.500,0.751 and 0.753,respectively,P ＜0.05).The serum levels of KL-6 were higher in patients with PAP who required whole lung lavage (WLL)or inhalation of granulocyte-macrophage colony-stimulating factor (GM-CSF) than those who did not [5 592.00 (1 738.00-9 982.00) U/mlvs.1 329.00 (1 017.75-3 543.75) U/ml,U=101.00,P＜ 0.05].Conclusion PAP patients had significantly higher levels of serum IL-13 and KL-6.The serum levels of KL-6 may reflect the severity of the disease and be taken as a marker of the necessity of treatment in PAP patients.
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