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慢性阻塞性肺疾病与睡眠呼吸疾病重叠综合征的诊断与治疗
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Tuberculosis and Respiratory Diseases
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1001-0939.2014.12.001
- Key Word:
- No keyword available
Abstract： 慢性阻塞性肺疾病(简称慢阻肺)和阻塞性睡眠呼吸暂停(OSA)二者共存即为重叠综合征.重叠综合征对患者的损害远大于单纯慢阻肺或者OSA,例如重叠综合征患者更容易出现心血管病变,最近一项利用核磁共振成像进行的试探性研究结果发现,重叠综合征患者与单纯慢阻肺患者相比,其右心室肥厚及右心室的重塑更加严重[1].另一项研究结果发现重叠综合征患者的β-脑钠肽比单纯慢阻肺患者高,血管的紧张度也高于单纯慢阻肺患者[2].大规模流行病学调查结果显示重叠综合征患者的病死率、住院率高于单纯慢阻肺或单纯OSA患者[3-4].重叠综合征患者由于存在反复呼吸暂停,因此可在慢阻肺病变的基础上进一步加重夜间低氧血症,导致肺动脉高压和肺源性心脏病等心脑血管疾病的发生率增高,慢阻肺急性加重的频率也更高,病死率更高[5].
- [1]徐靖,袁红,伍颖欣,等.慢性阻塞性肺疾病患者夜间低通气与呼吸中枢驱动的关系[J].2013,(6).
- [2]Samet J,Sanders MH,Punjabi NM,etc.Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease.[J].2003,167(1).
- [3]Michael L. Stanchina,Lauren M. Welicky,Walter Donat,etc.Impact of CPAP Use and Age on Mortality in Patients with Combined COPD and Obstructive Sleep Apnea:The Overlap Syndrome[J].2013,9(8).
- [4]A, Chaouat,E, Weitzenblum,J, Krieger,etc.Prognostic value of lung function and pulmonary haemodynamics in OSA patients treated with CPAP.[J].1999,13(5).
- [5]郭红喜,罗远明.重叠综合征的诊断与治疗[J].2012,15(11).
- [6]Zhihui Qiu,Ning Song,Sichang Xiao,etc.Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in Chinese patients with obstructive sleep apnoea.[J].2013,18(3).
- [7]Sharma,B.,Mandry,D.,Neilan,T.G.,etc.Evaluation of right ventricular remodeling using cardiac magnetic resonance imaging in co-existent chronic obstructive pulmonary disease and obstructive sleep apnea[J].2013,10(1).
- [8]Marin,J.M.,Soriano,J.B.,Carrizo,S.J.,etc.Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: The overlap syndrome[J].2010,182(3).
- [9]Yuan-Ming Luo,Bai-Ting He,Yin-Xin Wu,etc.Neural respiratory drive and ventilation in patients with chronic obstructive pulmonary disease during sleep.[J].2014,190(2).
- [10]Brian, Mieczkowski,Michael E, Ezzie.Update on obstructive sleep apnea and its relation to COPD.[J].2014,9.
- [11]Yoshida,M.,Kato,K.,Odaira,M.,etc.Overlap syndrome: Additive effects of COPD on the cardiovascular damages in patients with OSA[J].2012,106(9).
- [12]Ceriana,P.,Hill,N.,Schreiber,A.,etc.Physiological changes during low- and high-intensity noninvasive ventilation[J].2012,39(4).
- [13]Young, Terry,Palta, Mari,Dempsey, Jerome,etc.The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults.[J].1993,328(17).