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结核病与铁代谢关系的研究进展
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Tuberculosis and Respiratory Diseases
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1001-0939.2014.10.020
- Key Word:
- No keyword available
Abstract： 结核病是由MTB所致的以呼吸系统感染为主的慢性传染病,也是单一致病菌感染导致死亡率最高的感染性疾病,是传染病中的头号杀手,且近年来结核病疫情严重.据世界卫生组织(WHO)统计,2012年我国结核病年发病人数为103万,占全球年发病率的12％,位居全球第2位[1].巨噬细胞是MTB在体内的主要宿主细胞[2].研究发现铁代谢与细胞内感染有一定关系[3],巨噬细胞的铁代谢与MTB的生长繁殖密切相关[4],铁对于MTB在巨噬细胞内的生长至关重要.铁可促进MTB的增长.刘智等[5]认为血清铁水平可作为结核病诊断及疗效的重要辅助指标之一.现将巨噬细胞和MTB铁代谢与结核病的关系综述如下.
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