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支气管哮喘及焦虑与NPSR1基因多态性的相关性研究

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 5

DOI:: 10.3760/cma.j.issn.1001-0939.2014.05.013

Key Word:: No keyword available

Abstract：支气管哮喘(简称哮喘)是由多种细胞(包括气道的炎症细胞和结构细胞)和细胞组分参与的气道慢性炎症性疾病.虽然规范化治疗和哮喘自我管理对于控制哮喘急性发作起到了显著效果,但是由于尚无有效的根治办法,即使控制良好的哮喘患者也普遍存在心理问题,而焦虑和抑郁作为其重要的伴发疾病,与哮喘控制的程度及预后相关[1].哮喘患者中焦虑症的发病率是普通人群的6倍[2].进一步研究结果显示,哮喘与焦虑共病现象的机制可能与共享遗传易损性相关.神经肽S(NPS)-神经肽S受体1(NPS-NPSR1)系统可能在这两种疾病中起着遗传联锁作用[3-5].

Reference

[1]韩宏志,李波,孔宁,等.GPRA基因rs324396位点单核苷酸多态性与儿童支气管哮喘的相关性研究[J].2006,(4).
[2]Cannella N,Economidou D,Kallupi M.Persistent increase of alcohol-seeking evoked by neuropeptide s: an effect mediated by the hypothalamic hypocretin system.[J].2009,34(9).
[3]Pulkkinen V,Majuri ML,Wolff H,etc.Neuropeptide S and G protein-coupled receptor 154 modulate macrophage immune responses.[J].2006,15(10).
[4]Grotegerd D,Arolt V,Stuhrmann A,etc.Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli.[J].2011,36(9).
[5]Ring SM,Hall IP,Strachan DP,etc.Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort.[J].2009,64(5).
[6]Zhu H,Perkins C,Mingler MK,etc.The role of neuropeptide S and neuropeptide S receptor 1 in regulation of respiratory function in mice.[J].2011,32(4).
[7]Wang B,Yang J,Xu X,etc.G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population.[J].2006,117(3).
[8]Volker Arolt,Katharina Domschke,Peter Zwanzger,etc.Neuropeptide S receptor (NPSR1) gene variation modulates response inhibition and error monitoring.[J].2013,71(1).
[9]Rainer K.Reinscheid,Naoe Okamura,Joanne Zeng,etc.Pharmacological Characterization of Human and Murine Neuropeptide S Receptor Variants[J].2005,315(3).
[10]Joshua G. McCoy,Juan J. Marugan,Ke Liu,etc.Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines As Antagonists of the Neuropeptide S Receptor[J].2010,1(8).
[11]Hanna, Trzcińska,Grzegorz, Przybylski,Bartosz, Koz?owski,etc.Analysis of the relation between level of asthma control and depression and anxiety.[J].2012,18.
[12]宁宇,李波,李善玉,等.GPRA基因多态性与儿童支气管哮喘的关联性[J].2008,(4).
[13]Holsboer F,Gloster AT,Fehm L,etc.Neuropeptide S receptor gene -- converging evidence for a role in panic disorder.[J].2011,16(9).
[14]Civelli O,Reinscheid RK,Zeng J,etc.Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.[J].2004,43(4).
[15]Thomas M,Price D.Impact of comorbidities on asthma.[J].2008,4(6).
[16]Chen,F.S.,Kumsta,R.,Heinrichs,M.,etc.Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans[J].2013,93(2).
[17]Oomura Y,Sasaki K,Nakajima K,etc.Electrophysiological effects of neuropeptide S on rat ventromedial hypothalamic neurons in vitro.[J].2010,31(4).
[18]Chowen JA,de-Lecea L,Picetti R,etc.Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice.[J].2009,29(13).
[19]Chauveau,F.,Jüngling,K.,Lesting,J.,etc.Prevention of stress-impaired fear extinction through neuropeptide S action in the lateral amygdala[J].2012,37(7).
[20]Zucchelli M,Silander K,Pirkola S,etc.Assessment of the neuropeptide S system in anxiety disorders.[J].2010,68(5).