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低氧诱导因子-1在阻塞性睡眠呼吸暂停低通气综合征病理机制研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 5

DOI:: 10.3760/cma.j.issn.1001-0939.2013.05.017

Key Word:: No keyword available

Abstract： OSAHS的病理特点是间歇低氧及睡眠片断化.低氧诱导因子-1(hypoxia inducible factor-1,HIF-1)是细胞对低氧适应性调节的关键转录因子之一,由α、β两种亚基组成.缺氧时,信号经由HIF-lα的传递主要通过cAMP和蛋白磷酸化途径,使α、β在核内形成二聚体,在其他转录辅助激活因子的协同下,调控一系列包括与低氧适应、炎症发生发展及细胞增殖等相关的近100种靶基因的表达[1].目前认为,OSAHS的主要病理生理基础是睡眠过程中反复发生的间歇低氧,致氧化应激和炎症反应增强,诱导相关易感基因表达及炎症蛋白等生物活性物质的合成,进而导致多器官系统性损害,HIF-1是其中的关键调控因子之一.

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