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结核病的体液蛋白质组学研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 3

DOI:: 10.3760/cma.j.issn.1001-0939.2013.03.013

Key Word:: No keyword available

Abstract：蛋白质组学是一门新兴学科,运用该技术可以在正常与病理情况下检测蛋白质的差异表达,获得相应的疾病标志物,其甲体液蛋白质组学对发现人类疾病生物标志物具有广阔的发展前景[1].近年来通过血清、胸腔积液、脑脊液、BALF和痰液等体液蛋白质组学研究,发现与结核病相关的重要功能蛋白质,这些蛋白质为寻找疾病标志物及研究结核病发病机制提供有价值的线索.笔者对目前常用的蛋白质组学相关技术及体液蛋白质组学在结核病研究中的进展综述如下.一、蛋白质组学研究技术进展目前,蛋白质组学技术从大体上可分为3类,即表面增强激光解析离子化飞行时间质谱(surface-enhanced laser desorp[ion/ionization time of flight mass spectrometry,SELDITOF-MS)、基于胶分离的技术和鸟枪法蛋白质组学(shot gun proteomics)技术.

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