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Application of gene typing approach based on variable-number tandem repeats-mycobacterial interperse repetitive units in the epidemiological study of Mycobacterium tuberculosis

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES

Issue:: 5

DOI:: 10.3760/j:issn:1001-0939.2005.05.018

Key Word:: No keyword available

Abstract： @@ 结核病是一种严重影响人类健康的传染病.全球有近1/3人口感染了结核分枝杆菌,主要分布在发展中国家.如果不能及时和有效地控制结核病传播,在今后20年内,发展中国家将会有2亿人罹患结核病.在我国,三分之一人口已感染结核分枝杆菌,受感染人数超过4亿,其中约有10%发生结核病.如果不采取有效的措施,在未来十年内预计有3 000万人发生结核病.当前结核病控制面临的主要困难有:贫困人口的结核病发病率高、发现率低、耐药结核菌感染增多,而伴随着城市化过程的人口流动,更加剧了结核病在人群间的传播.为了有效地控制结核病传播,除了在全国范围内实施面向贫困人群的结核病控制专项项目外,还需建立完整、准确的结核病流行病学监测体系.分子流行病学是监测传染病传播的有效途径,它是建立在"感染相同菌株的患者有相同的传染源即存在分子流行病学联系"假设基础之上的,而分子流行病学在结核病基因分型中的应用,与传统流行病学相比能更准确地预测疾病的暴发流行及其传播模式.

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