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Clinical features and airway inflammation in eosinophilic bronchitis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES
- Issue:
- 6
- DOI:
- 10.3760/j:issn:1001-0939.2003.06.014
- Key Word:
- 嗜酸粒细胞性支气管炎;诱导痰;嗜酸粒细胞;诊断;气道炎症
Abstract： 目的探讨嗜酸粒细胞性支气管炎(eosinophilic bronchitis,EB)的诊断、治疗及其气道炎症特点.方法采用Irwin慢性咳嗽解剖学诊断程序,对86例慢性咳嗽患者进行病因诊断;通过诱导痰,分析痰液中细胞分类,分别采用荧光酶免疫法、酶联免疫吸附法测定诱导痰上清液中嗜酸粒细胞阳离子蛋白(ECP)、白细胞介素8(IL-8)的浓度,并以9例正常人和9例典型哮喘患者作对照组;吸入布地奈德干粉剂200～400μg,每天2次,治疗4周,部分患者同时口服泼尼松10～15 mg/d或甲泼尼龙8～12 mg/d,1周.结果本组有13例符合EB诊断,占慢性咳嗽的15%,多表现为慢性干咳,肺功能正常,组胺激发试验阴性.EB诱导痰嗜酸粒细胞(Eos)为0.186 2±0.163 2,ECP浓度为(2.53±2.07)mg/L,均较正常人升高(P＜0.01);糖皮质激素治疗1周后,13例患者的咳嗽均消失.结论EB是引起慢性咳嗽的一个重要原因,气道具有以Eos为主的炎症,糖皮质激素治疗效果良好.
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