You Position: Home > Paper

Methylenetetrahydrofolate reducatase polymorphism and asthma

( views:188, downloads:12 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES
Issue:
3
DOI:
10.3760/j:issn:1001-0939.2003.03.011
Key Word:
亚甲基四氢叶酸还原酶;基因型;半胱氨酸;哮喘

Abstract: 目的了解亚甲基四氢叶酸还原酶C/T多态性与支气管哮喘(简称哮喘)发生、发展的关系.方法用聚合酶链反应和限制性片段长度多态性分析法对433例哮喘患者和1 249例对照组患者进行MTHFR基因型分析.结果 MTHFR三种基因型的频率分别为:CC占40.27%,CT占48.44%,TT占11.29%, T等位基因的频率为35.51%.过敏性哮喘患者中TT基因型的频率与对照组比较,差异有显著性(P=0.026),与CC和CT基因型比较,其OR值为1.61,95%可信区间(95%CI)为1.06~2.47.结论 TT基因型是过敏性哮喘发病的危险因素.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn