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如何区分时间及浓度依赖性抗菌药物?有何临床意义?
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES
- Issue:
- 12
- DOI:
- 10.3760/j:issn:1001-0939.2002.12.009
- Key Word:
- No keyword available
Abstract： @@ 抗菌药物的疗效不仅取决于它对病原菌的最低抑菌浓度(MIC),同时也与它的药代动力学特点及抗菌药物后效应(PAE),即抗菌药物全部清除后细菌恢复生长的延迟时间等有关.近年来国外学者按照杀菌作用是否浓度依赖及有无PAE将抗菌药物分为浓度依赖性及时间依赖性两个大类.
- [1]张歆刚,刘又宁,王睿.丁胺卡那霉素日剂量单次与分两次给药方案的体内药效及毒性比较[J].2002,(5).
- [2]D N, Gilbert.Once-daily aminoglycoside therapy.[J].1991,35.
- [3]Craig, W. A..Interrelationship Between Pharmacokinetics and Pharmacodynamics in Determining Dosage Regimens for Broad Spectrum Cephalosporins[J].1995,22(1).
- [4]W.A.Craig.Antibiotic selection factors and description of a hospital-based outpatient antibiotic therapy program in the USA[J].1995,14(7).
- [5]A, Forrest,D E, Nix,C H, Ballow,etc.Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients.[J].1993,37.