Changes of proinflammatory cytokines and their receptors in serum from patients with pulmonary tuberculosis
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES
- Issue:
- 6
- DOI:
- 10.3760/j:issn:1001-0939.2002.06.002
- Key Word:
- 结核,肺;肿瘤坏死因子α;白细胞介素1β;白细胞介素6
Abstract： 目的探讨肺结核患者血清TNF-α及受体、IL-1β及受体、IL-6及受体的特征及其临床意义,并明确其在结核病免疫发病中的作用.方法采用双抗体夹心ABC-ELISA法检测41例活动性肺结核患者、21例非活动性肺结核患者和20名正常人血清TNF-α、sTNF-RⅠ、IL-1β、IL-1R、 IL-6、 IL-6R的水平,同时对17例活动性肺结核患者抗结核治疗后上述CK水平进行了随访.结果活动性肺结核组和非活动性肺结核组血清TNF-α、sTNF-RⅠ、IL-1β、IL-1R、 IL-6、 IL-6R水平及TNF-α/sTNF-RⅠ比值均显著高于正常对照组(P<0.01～0.05).活动性肺结核组血清TNF-α、sTNF-RⅠ、IL-1β、IL-1R、 IL-6、 IL-6R水平及TNF-α/sTNF-RⅠ比值显著高于非活动性肺结核组(P<0.01～0.05).空洞组血清TNF-α、sTNF-RⅠ、IL-1β、 IL-6水平及TNF-α/sTNF-RⅠ比值低于无空洞组(P<0.01～0.05).抗结核治疗2月末,17例患者中有15例患者血清TNF-α、sTNF-RⅠ、IL-1β、IL-1R、 IL-6、 IL-6R水平及TNF-α/sTNF-RⅠ比值均较治疗前明显降低(P<0.01～0.05),且上述患者临床症状改善,痰菌阴转,胸片病灶吸收好转、空洞缩小或闭合.但有2例患者血清上述CK水平较治疗前未明显降低,痰菌未阴转.结论 TNF-α、sTNF-R、IL-1β、IL-1R、IL-6、IL-6R等均参与结核病免疫发病过程.肺结核患者血清前炎细胞因子及受体水平的检测有助于了解疾病的活动性,判断病情及预后,监测抗结核治疗的效果.
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