You Position: Home > Paper
The pathology of and the cardio-pulmonary functional changes in acute multiple pulmonary microthromboembolism in a canine model
( views:260, downloads:64 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES
- Issue:
- 4
- DOI:
- 10.3760/j:issn:1001-0939.2002.04.008
- Key Word:
- 肺血栓栓塞症,微小血栓;病理生理学
Abstract： 目的了解多发性肺动脉微小血栓栓塞在犬动物模型中对肺组织形态、循环功能、呼吸功能和凝血纤溶指标的影响.方法健康成年杂种犬13只,随机分为2组,栓塞组7只,对照组6只.取自体血10 ml制成1～2 mm大小血栓,给栓塞组动物1次注入300个微小血栓,检测栓塞前、栓塞即刻、30 min、1 h和2 h,血流动力学和氧动力学的变化.结果肺栓塞后即刻出现肺动脉压(PAP)明显升高,1 h后下降.对通气功能影响不大.D-二聚体(D-dimer)在30 min后开始升高.病理可见肺出血、肺实变和微小动脉血栓形成.结论肺动脉微小血栓栓塞可引起肺组织水肿、出血和肺动脉内血栓形成,并在栓塞早期引起肺动脉高压.但对通气功能的影响不明显,D-dimer在微小血栓栓塞早期即有明显变化.
- [1]S K, Lo,M B, Perlman,G D, Niehaus,etc.Thrombin-induced alterations in lung fluid balance in awake sheep.[J].1985,58.
- [2]Sandra L. Beal,R.Lawerence Reed II,David Heimbach,etc.Pulmonary microembolism: A cause of lung injury[J].1987,43(4).
- [3]C A, Wagenvoort.Pathology of pulmonary thromboembolism.[J].1995,107(1 Suppl).