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Molecular diagnostic techniques in identification of mycobacterial species

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES

Issue:: 12

DOI:: 10.3760/j:issn:1001-0939.2001.12.037

Key Word:: No keyword available

Abstract： @@ 肺癌是目前世界上发病率和死亡率最高的一种恶性肿瘤[1,2],为了找到一个能准确估计疾病预后,对临床诊断和治疗有指导作用的生物学指标,我们对Her-2/Neu在肺癌中的相关研究进行了综合与分析.一、生物学性质1984年Schechter等第一次在乙基亚硝酸盐诱导的小鼠神经母细胞瘤中发现了一个转化基因,它与表皮生长因子具有完全同源性的核苷酸序列,称之为neu,后统称为Her-2/Neu.Neu基因位于17q21染色体上,它转录的mRNA 长度为4.8 kb,cDNA的长度为4.5 kb.Neu基因编码的蛋白位于细胞膜上,分子量为185×103,是一种跨膜糖蛋白,具有典型的细胞内酪氨酸激酶特性,以P185neu表示.

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