Abstract： Objective:To analyze the influencing factors of prognosis of hyperbaric oxygen therapy after minimally invasive hematoma evacuation in hypertensive intracerebral hemorrhage（HICH）.Methods:The clinical data of 40 HICH patients after minimally invasive hematoma evacuation in Fujian Provincial Hospital from January 2019 to June 2020 were retrospectively analyzed，who had poor prognosis［Glasgow outcome（GOS）score ≤ 3 points］，while another 40 HICH patients had good prognosis（GOS score >3 points）treated in the same time period were selected. The data of all 80 patients were well recorded. The baseline data forms were designed and filled，according to the patients’ medial files. The univariate and multivariate analyses were conducted to find out the influencing factors of poor prognosis of hyperbaric oxygen therapy after minimally invasive hematoma evacuation in HICH.Results:The patients in the poor prognosis group suffered severer coma than those in the good prognosis group. The proportions of patients with bleeding volume over 30 ml（60.00%，24/40）and midline shift（45.00%，18/40）in the poor prognosis group were higher than those in the good prognosis group（35.00% and 22.50%，respectively），with statistically significant differences（ P<0.05）；the intervention timing of postoperative hyperbaric oxygen treatment in the poor prognosis group was（14.62 ± 2.31）d，which was later than that in the good prognosis group（8.61 ± 2.45）d. The level of interleukin-18（IL-18）in the poor prognosis group（292.31 ± 30.45）ng/L was higher than that in the good prognosis group（208.45 ± 28.62）ng/L，with statistically significant difference（ P<0.05）. There was no statistically significant difference in other data between the two groups（ P>0.05）. The logistic regression analysis showed that severe coma at admission，excessive bleeding，midline shift，late intervention timing of hyperbaric oxygen therapy after operation，and over-expression of IL-18 level at admission were the influencing factors of poor prognosis of hyperbaric oxygen therapy after minimally invasive hematoma evacuation in HICH. Conclusion:The poor prognosis of hyperbaric oxygen therapy after minimally invasive hematoma evacuation in HICH can be related to severe coma at admission，excessive bleeding，midline shift，late intervention timing of hyperbaric oxygen therapy after operation，and over-expression of IL-18 level at admission.