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Network pharmacological analysis of the molecular mechanism of Duhuo Jisheng( Angelicae pubescentis and loranhti)decoction in the treatment of osteonecrosis and the implications for the treatment of dysbaric osteonecrosis

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Journal Title:
Chinese Journal of Health Management
Key Word:
网络药理学;独活寄生汤;减压性骨坏死;靶点预测;Network pharmacology;Duhuo Jisheng decoction;Dysbaric osteonecrosis;Target prediction

Abstract´╝Ü Objective:To screen the main active compounds of Duhuo Jisheng( Angelicae pubescentis and loranhti)Decoction by means of network pharmacology,to predict relevant targets and possible mechanisms of these active compounds in the treatment of osteonecrosis,and to provide reference for possible treatments for dysbaric osteonecrosis. Methods:We searched and screened the active compounds and targets of Duhuo Jisheng Decoction on the Traditional Chinese Medicine Systems Pharmacology Database,and identified the targets related to osteonecrosis in the disease gene databases. We used software to construct the network of "ingredient-compound-target" and the Venn diagram of "ingredient-disease",and obtain the intersection targets of Duhuo Jisheng Decoction and osteonecrosis. Then the protein-protein interaction network was constructed and Gene Ontology(GO)functional annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed.Results:A total of 226 active compounds,271 potential targets,and 468 osteonecrosis-related targets were screened. A total of 61 "ingredient-disease" intersection targets were obtained,among which the core targets included VEGFA,IL1B,TNF,ALB,IL6,mainly enriched in the biological processes such as positive regulation of cell death and the signaling pathways of HIF-1 and NF-κB.Conclusion:Duhuo Jisheng Decoction may treat osteonecrosis by regulating VEGFA,IL1B,TNF,ALB,IL6,and other targets through HIF-1,NF-κB,and other signaling pathways to inhibit inflammation,promote angiogenesis,and osteoblast proliferation,hence a possible treatment of dysbaric osteonecrosis.

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