Abstract： Objective:To investigate the effect of hyperbaric oxygen（HBO）therapy on cerebral infraction in elderly patients and its influence on hemodynamic and hemorheological parameters.Methods:A total of 152 elderly patients with cerebral infarction admitted to the First Affiliated Hospital of Naval Medical University from January 2020 to June 2021 were selected as the research subjects and randomly divided into HBO group and control group，with 76 cases in each group. The changes of neurologic function scores and ultrasonic hemodynamic and hemorheological parameters before and after treatment were compared between the two groups.Results:After treatment，the NIHSS scores of the patients in the HBO treatment group were lower than those of the control group（ P<0.05），while the MoCA（Chinese version）score and Barthel Index in the HBO group were higher than those of the control group（ P<0.05）. The total effective rate，hemodynamic and hemorheological parameters of the patients in the HBO group were superior to those in the control group，with statistically significant differences（ P<0.001）. Conclusion:Compared with conventional treatment，HBO treatment has a more significant effect on cerebral infarction in elderly patients. It can positively promote the recovery of elderly patients’ cognitive function and activities of daily living，improve blood circulation and hemodynamic parameters.