Abstract: Objective:To conduct a clinical study on acupuncture combined with hyperbaric oxygen and medication in the treatment of sudden deafness,and observe the curative effect.Methods:A total of 228 patients with sudden deafness admitted to the Department of Rehabilitation Medicine of Shaanxi Provincial People’s Hospital from January 2019 to January 2021 were randomly divided into treatment group( n=121)and control group( n=107). The control group received acupuncture and medication therapy,while the treatment group received hyperbaric oxygen therapy on the basis of the control group. Before observing the efficacy,each group was treated for seven times. Results:The marked response rate of the treatment group was 68.6%,and the overall response rate was 85.1%;while the marked response rate of the control group was 57.9%,and the overall response rate was 71.0%. There were statistically significant differences between the two groups( P<0.05). Conclusion:Hyperbaric oxygen combined with acupuncture and medication is more effective than using acupuncture and medication alone in the treatment of sudden deafness.