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Study on the anti-motion sickness effect of atrial natriuretic peptide in rats

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Journal Title:
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
Key Word:
大鼠;运动病;精氨酸加压素;心房钠尿肽;Rat;Motion sickness;Arginine vasopressin;Atrial natriuretic peptide

Abstract´╝Ü Objective:To study the anti-motion sickness effect of atrial natriuretic peptide(ANP)through establishing two types of motion sickness rat models by giving rotational stimulation or intraperitoneal arginine vasopressin(AVP)injection.Methods:Normal Sprague-Dawley rats were rotated 120 min to induce motion sickness. The behavioural changes in their ingestion of 0.15% saccharin sodium solution(SSS)and consumption of kaolin were measured;and the susceptibilities of the rats to motion sickness were thus determined. The behavioural changes in the ingestion of 0.15% SSS after the intraperitoneal injection of AVP were also recorded. Finally,after the intraperitoneal injection of ANP,inhibitory influences on taste aversion to 0.15% SSS induced by these two methods were determined.Results:After the rotational stimulation,the rats reduced their intake of 0.15% SSS(taste aversion)or increased the intake of kaolin(pica). The intraperitoneal injection of AVP in rats could also induce taste aversion to 0.15% SSS. However,the intraperitoneal injection of ANP effectively inhibited this conditioned taste aversion to 0.15% SSS induced either by rotational stimulation or AVP injection.Conclusion:Both rotational stimulation and intraperitoneal injection of AVP could induce motion sickness;and the intraperitoneal injection of ANP could help relieve motion sickness in rats.

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