Abstract： Objective:To study the anti-motion sickness effect of atrial natriuretic peptide（ANP）through establishing two types of motion sickness rat models by giving rotational stimulation or intraperitoneal arginine vasopressin（AVP）injection.Methods:Normal Sprague-Dawley rats were rotated 120 min to induce motion sickness. The behavioural changes in their ingestion of 0.15% saccharin sodium solution（SSS）and consumption of kaolin were measured；and the susceptibilities of the rats to motion sickness were thus determined. The behavioural changes in the ingestion of 0.15% SSS after the intraperitoneal injection of AVP were also recorded. Finally，after the intraperitoneal injection of ANP，inhibitory influences on taste aversion to 0.15% SSS induced by these two methods were determined.Results:After the rotational stimulation，the rats reduced their intake of 0.15% SSS（taste aversion）or increased the intake of kaolin（pica）. The intraperitoneal injection of AVP in rats could also induce taste aversion to 0.15% SSS. However，the intraperitoneal injection of ANP effectively inhibited this conditioned taste aversion to 0.15% SSS induced either by rotational stimulation or AVP injection.Conclusion:Both rotational stimulation and intraperitoneal injection of AVP could induce motion sickness；and the intraperitoneal injection of ANP could help relieve motion sickness in rats.