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Effects of hyperbaric oxygen therapy on levels of serum NSE and ET-1 and on cerebral hemodynamic indicators in children with severe viral encephalitis

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Author:
No author available
Journal Title:
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
Issue:
6
DOI:
10.3760/cma.j.cn311847-20201111-00420
Key Word:
高压氧;病毒性脑炎;神经元特异性烯醇化酶;内皮素;脑血流动力学;Hyperbaric oxygen;Viral encephalitis;Neuron-specific enolase;Endothelin;Cerebral hemodynamics

Abstract: Objective:To explore the effects of hyperbaric oxygen therapy (HBOT) on levels of serum neuron-specific enolase (NSE) and endothelin (ET-1) and on cerebral hemodynamic indicators in children with severe viral encephalitis (VE).Methods:The children with severe VE admitted to Yantai Mountain Hospital from January 2016 to June 2019 were selected as research subjects and were divided into observation group ( n=45) and control group ( n=45) by random number table method. Both groups were given conventional treatment, and the observation group was additionally treated with HBOT. The mean flow velocity (Vm) and pulsatility index (PI) of anterior cerebral artery (ACA), posterior cerebral artery (PCA), vertebral artery (VA), and basal artery (BA), and the levels of serum NSE and ET-1 were measured before treatment and after two courses of treatment. Results:The therapeutic effects were evaluated and the incidences of sequelae during the six-month follow-up were counted. The total effective rate in the observation group (93.33%) was higher than that in the control group (77.78%), with a statistically significant difference ( P<0.05). After treatment, ACA-PI and Vm of PCA, VA, and BA in the observation group were lower than those before treatment and those at the same time points in the control group after treatment ( P<0.05). After treatment, the levels of serum NSE and ET-1 in both groups were decreased ( P<0.05); and the observation group showed a greater decrease than the control group, with a statistically significant difference ( P<0.05). The incidence of sequelae in the observation group (4.44%) was lower than that of the control group (17.78%), with a statistically significant difference ( P<0.05). Conclusion:HBOT can promote the recovery of cerebral hemodynamic indicators and reduce brain damage in children with severe VE.

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