Abstract： Objective:To investigate the clinical effect of hyperbaric oxygen (HBO) combined with fructose diphosphate sodium on child patients with myocardial injury induced by acute carbon monoxide (CO) poisoning.Methods:A total of 96 cases of acute CO poisoning child patients admitted to the Department of Pediatrics of the Affiliated Hospital of Jining Medical University from December 2012 to December 2019 were selected and randomly divided into control group and observation group according to the random number table method, with 48 cases in each group. The control group was given conventional symptomatic and supportive treatment combined with HBO, while the observation group was given fructose diphosphate sodium on the basis of the treatments in the control group. The clinical effect, the Glasgow coma scale (GCS) score, the levels of serum creatine kinase-MB (CK-MB), cardiac troponin I (cTnⅠ), brain natriuretic peptide (BNP), myoglobin (MYO), creatine kinase (CK), and α-hydroxybutyrate dehydrogenase (α-HBDH) of the two groups were observed.Results:After treatment, the GCS scores and the levels of serum CK-MB, cTnⅠ, MYO, BNP, CK, and α-HBDH of the two groups were significantly improved compared with those before treatment, all with statistically significant differences ( P<0.05 or P<0.01). The total effective rate of the observation group (97.92%) was significantly higher than that of the control group (91.67%), with statistically significant difference ( P<0.05). After treatment, the GCS score of the observation group was significantly higher than that of the control group; the serum expression levels of CK-MB, cTnⅠ, MYO, BNP, CK, and α-HBDH in the observation group were significantly lower than those in the control group; the total effective rate of electrocardiogram improvement in the observation group (93.75%) was significantly higher than that in the control group (85.42%), all the above differences were statistically significant ( P<0.05 or P<0.01). Conclusion:HBO combined with fructose diphosphate sodium can enhance the clinical curative effect on child patients with acute CO poisoning by promoting their regain of consciousness and improving the myocardial injury.