Abstract： Objective To investigate the efficacy of antidepressant Deanxit in the treatment of irritable bowel syndrome (IBS) and functional dyspepsia (FD) overlap syndrome.Methods One hundred and twentyeight patients with IBS and FD overlap syndrome admitted into the Jiangwan Hospital of Hongkou District,Shanghai for medical treatment from March,2014 to December,2017 were randomly divided into the control group and the observation group,each consisting of 64 patients.The control group received pinaverium bromide and omeprazole,while the observation group was treated with Deanxit.The differences in the efficacy,the Hamilton anxiety rating scale(HAMA) and the Hamilton depression rating scale (HAMD) were compared and analyzed between the patients of the 2 groups.Results Total effective rate of the observation group was 96.7％,which was significantly higher than that of the control group,and statistical significance could be seen when comparisons were made between the 2 groups (P ＜ 0.01).After intervention,both the HAMD and HAMA scores in the observation group decreased notably and were significantly lower than those in the control group,with statistical significance (P ＜ 0.01).Conclusion Deanxit could achieve sure results in the treatment of IBS and FD overlap syndrome,effectively improve clinical symptoms and relieve anxiety or depression.Therefore,it is worth clinical promotion.