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高压氧治疗炎症性肠病的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Nautical Medicine and Hyperbaric Medicine

Issue:: 5

DOI:: 10.3760/cma.j.issn.1009-6906.2018.05.016

Key Word:: No keyword available

Abstract：炎症性肠病( inflammatory bowel disease ,IBD)包括溃疡性结肠炎( ulcerative colitis, UC )和克罗恩病( Crohn ' s disease, CD),是一种病因未明的非特异性肠道炎症性疾病.IBD的治疗主要包括药物及手术,但仍有部分患者由于药物不良反应及手术并发症等因素导致疗效欠佳. 因此,探寻新的IBD治疗方法成为亟需. 高压氧治疗( hyperbaric oxygen therapy,HBOT)是一种使患者间歇性吸入100％纯氧,并且治疗舱加压大于海平面压力(即1.0 个绝对大气压)的疗法. HBOT最早用于CO中毒的治疗,但近年来发现其对于多种疾病均能起到缓解作用. 尽管在临床上已有一些案例用HBOT来治疗IBD及其并发症,但是具体的作用机制以及治疗方案均没有肯定的结论,本文对HBOT治疗IBD作一综述,为探究HBOT作用机制以及临床应用提供新的思路.

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