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高压氧治疗顺铂性耳聋的理论基础和临床价值

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Author:
No author available
Journal Title:
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
Issue:
6
DOI:
10.3760/cma.j.issn.1009-6906.2017.06.028
Key Word:
No keyword available

Abstract´╝Ü 顺铂性耳聋是癌症患者在应用顺铂化疗时引起的听力损伤,轻则听力减退,重则听力完全丧失. 大约有 60% ~80%的患者在应用顺铂进行化疗时出现听阈提高,大约15%的患者出现严重的听力障碍[1] ,而且这种听力损伤往往是双侧进行性、不可逆性的,听力损失常发生在 4000 ~8000 Hz的高频区,并逐渐向中、低频区听力累及,且接受化疗次数越多听力损伤越严重,因此顺铂的耳毒性是影响患者抗癌治疗乃至停药的重要原因[2] .

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