Abstract： Objective To investigate the effects of hyperbaric oxygen (HBO)combined with herbal "scorpion seven" on the expression levels of stromal cell-derived factor-1/chemokine receptor-4 (SDF1/ CXCR4) in the plasma of the patients with acute spinal cord injury (ASCI).Methods Sixty patients with acute incomplete spinal cord injury were chosen for the study,and were divided into the control group (n =30)which was treated with conventional drug therapy plus HBO and the treatment group (n =30) which received herbal " scorpion seven" treatment in addition to conventional drug therapy plus HBO therapy.Close observations were made on expression levels of SDF1/CXCR4 receptors in plasma at the same time points before therapy,and at day 10,day 30,day 60 and day 90.Results As compared with those of the patients of the control group,the expression levels of SDF1/CXCR4 and VEGF in the plasma of the patients with ASCI were significantly increased,at day 10,day 30,day 60 and day 90 after treatment,and statistical significance could be seen when comparisons were made between the 2 groups (P ＜0.05).Peak value appeared at day 10,and the expression levels of SDF1/CXCR4 and VEGF at day 90 after treatment were still higher than the baseline of initial injury.Conclusions HBO combined with herbal "scorpion seven" could promote the recovery of vascular endothelial function in the patients with ASCI through the access of increasing the levels of SDF1/ CXCR4 and VEGF in peripheral blood.