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Enhancing effect of hyperbaric oxygen on the chemotherapeutic drugs in the treatment of gastric cancer and its possible mechanism

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Author:
No author available
Journal Title:
中华航海医学与高气压医学杂志
Issue:
6
DOI:
10.3760/cma.j.issn.1009-6906.2015.06.008
Key Word:
高压氧;胃癌;5-氟尿嘧啶;顺铂;增殖;Hyperbaricoxygen;Gastriccancer;5-Fu;Cisplatin;Proliferation

Abstract: Objective To investigate the effect of chemotherapeutic drugs combined with HBO on the proliferation? inhibition in gastric adenocarcinoma cell line SGC 7901.Methods Following pretreatment with HBO, the SGC7901 cells were treated with the chemotherapeutic drugs of cisplatin or 5-Fu respectively .MTT assay was performed to detect the proliferation of cells .After treatment of SGC7901 cells with HBO, the effect of HBO on the cell cycle was detected by flow cytometry .Results HBO treatment could affect cell proportion cycle, significantly increasing S phase cell proportion , while decreasing G0/G1 phase cell proportion .HBO pretreatment could improve the inhibitive effect of 5-Fu on SGC7901 cells, but it would not affect the proliferative effect of cisplatin on SGC7901 cells.Conclusions HBO pretreatment could obviously promote the anti-neoplastic effect on cell cycle specific agent 5-Fu, but it seemed to have no significant inhibitory effect on the cell cycle non-specific agent cisplatin in the treatment of gastric cancer patients .The mechanism involved might be possibly associated with the cell cycle and the increase in S phase cell proportion of SGC 7901.

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