Abstract： Objective To analyze the effects of intervention on the migraine patients with comorbidity of depression and anxiety among offshore marine personnel.Methods One hundred and forty-two migraine patients that met the migraine,depression and anxiety diagnostic standards were chosen from the offshore marine personnel,and were randomly divided into 2 groups,each consisting of 71 patients.At the onset of the disease,the patients of both groups were given painkillers,and during remission they were administered with preventive drugs (SNRI) for the recurrence of the disease.One of the groups was provided with additional treatment of 5-hydroxytryptamine and noradrenergic inhibitor.Migraine attack frequency,Visual Analogue Score (VAS),SF-36 Health Survey Scale,Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) evaluation results were recorded both before treatment and at week 6 and 12 after treatment.The whole observation period lasted for 12 weeks.Results At week 6,migraine attack frequency and visual analogue scores for the venlafaxinc treatment group were obviously reduced,as compared with those of the nonvenlafaxine treatment group(P ＜ 0.05),while the mode of depression was obviously improved (HAMD value,P ＜0.05).However,no changes could be seen in the mode of anxiety (HAMA value,P ＜ 0.05).For the venlafaxine treatment group,the scores of physiological function (PF),body pain (BP),general hcalth (GH) status,vitality (VT) of SF-36 were higher than those of the non-venlafaxine treatment group (P ＜ 0.01 and P ＜0.05).At week 12,attack frequency and visual analogue scores were significantly reduced,as compared with the non-venlafaxine treatment group (P ＜ 0.01),while the depression and anxiety scores obviously improved (HAMD value,P ＜ 0.01 ; HAMA value,P ＜ 0.05).For the venlafaxine treatment group,the scores of RP,BP,GH,VT,social function (SF),RE,mental health (MH) of SF-36 were higher than those of the non-venlafaxine treatment group(P ＜ 0.01).Conclusions Treatment of migraine patients with comorbidity of depression and anxiety by using anti-depression and anti-anxiety drugs could obviously reduce migraine attack frequency,seriousness of pain and in the mean time improve the status of mental disorder and the life quality of the patients as well.