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Effects of hyperbaric oxygen on the hearing of inner ear and the hormone levels of HPA axis in rats induced by adrenaline

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Author:
No author available
Journal Title:
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
Issue:
4
DOI:
10.3760/cma.j.issn.1009-6906.2014.04.003
Key Word:
应激;糖皮质激素;高压氧;肾上腺素;听力损害;Stress;Glucocorticoid;Hyperbaric oxygen;Adrenaline;Hearing damage

Abstract: Objective To observe the effects of hyperbaric oxygen (HBO) on the damage of inner ear and hearing loss induced by adrenaline and also to monitor changes in hormone levels related with stress,so as to evaluate effects of HBO on hearing damage and related stressors.Methods Twenty-four male Wistar rats were randomly divided into 3 groups:the blank control group,the adrenaline group and the adrenaline plus HBO group.Infusion of adrenaline through the access of middle ear for a succession of 5 days till hearing loss was induced,while the animals in the control group were only given physiologic saline.After completion of medication,the animals in the HBO group received HBO therapy 1 session / a day for 3 consecutive days,and the animals in the other 2 groups were left untreated for natural recovery.Changes in hearing thresholds in rats were detected through monitoring of evoked auditory brainstem response (ABR).After termination of the experiment,the animals were sacrificed for detection of serum hormone levels.Results The administration of adrenaline through the access of middle ear could elevate the hearing threshold of the rats.The final hearing threshold of the rats in the HBO group [(26.01 ± 7.95) dB] was lower than that of the adrenaline group [(39.69 ± 8.26) dB] (P < 0.05).Cortisol level in the animals of the control group was the lowest,followed by the animals in the HBO group.The cortisol level in the animals of the model group was the highest.Conclusions HBO therapy could alleviate hearing damage of the rats induced by adrenaline.Cortical levels were closely associated with the seriousness of hearing damage.

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